The kidney is the central organ involved in maintaining water and sodium balance. in human kidneys, nine aquaporins (aqps), including aqp1-8 and aqp11, have been found and are differentially expressed along the renal tubules and collecting ducts with distinct and critical roles in the regulation of body water homeostasis and urine concentration.. In the kidney at least 7 aquaporins are expressed at distinct sites. aqp1 is extremely abundant in the proximal tubule and descending thin limb and is essential for urinary concentration. aqp2 is exclusively expressed in the principal cells of the connecting tubule and collecting duct and is the predominant vasopressin-regulated water channel.. In the kidney at least 7 aquaporins are expressed at distinct sites. aqp1 is extremely abundant in the proximal tubule and descending thin limb and is essential for urinary concentration. aqp2 is....
Aquaporin-1 (aqp1) is the major water channel in the renal proximal tubule and the loop of henle. 1 these two nephron segments are responsible for reabsorbing 80% of the glomerular filtrate. 1 as.... At least five aquaporins have been identified in the kidney; they have provided detailed molecular insight into the fundamental physiology of water balance. this article focuses primarily on the physiology and pathophysiologic significance of the vasopressin-regulated water channel aquaporin-2 (aqp2) in a number of conditions where body water. The identification and characterization of several aquaporins expressed in the kidney has allowed detailed insight, at the molecular level, into the fundamental physiology and pathophysiology of renal water metabolism..
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